Pathophysiology
Volume 18, Issue 4 , Pages 255-261 , September 2011

Antihyperglycemic and antioxidant activities of alcoholic extract of Commiphora mukul gum resin in streptozotocin induced diabetic rats

  • Ramesh Bellamkonda

      Affiliations

    • Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India
    • ,
  • Karuna Rasineni

      Affiliations

    • Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, Andhra Pradesh, India
    • ,
  • Sreenivasa Reddy Singareddy

      Affiliations

    • Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, Andhra Pradesh, India
    • ,
  • Ramesh Babu Kasetti

      Affiliations

    • Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India
    • ,
  • Ramatholisamma Pasurla

      Affiliations

    • Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India
    • ,
  • Appa Rao Chippada

      Affiliations

    • Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India
    • ,
  • Saralakumari Desireddy

      Affiliations

    • Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, Andhra Pradesh, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 08554 255879; fax: +91 08554 255805.

Received 1 October 2010 ,Accepted 23 October 2010.

References 

  1. Teixeira CC, Rava CA, Da Silva PM, Melchior R, Argenta R, Anselmi F, et al. Absence of antihyperglycemic effect of jambolan in experimental and clinical models. J. Ethnopharmacol. 2000;7:343–347
  2. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21:1414–1431
  3. Kameswara Rao B, Giri R, Kesavalu MM, Appa Rao Ch. Herbal medicine: in the management of diabetes mellitus. Manhar Vaidhya Patrika. 1997;1:33–35
  4. Larner J. The Pharmacological Basis of Therapeutics. 7th ed.. New York: Macmillan; 1985;
  5. Kameswara Rao B, Kesavalu MM, Appa Rao Ch. Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan-induced diabetic rats. Fitoterapia. 2003;74:7–13
  6. Ozsoy N, Can A, Yanardag R, Akev N. Antioxidant activity of Smilax excelsa L. leaf extracts. Food Chem. 2008;110:571–583
  7. Aruoma OL. Free radicals, oxidative stress and antioxidants in human health and diseases. J. Am. Oil Chem. Soc. 1998;75:199–212
  8. Duckworth WC. Hyperglycemia and cardiovascular disease. Curr. Atheroscler. 2001;3:381–391
  9. Kim MJ, Ryu GR, Chung JS, Sim SS, Min Dos Rhie DJ, Yoon SH, et al. Protective effect of epicatechin against the toxic effects of STZ on rat pancreatic islets: in vivo and in vitro. Pancreas. 2003;26:292–299
  10. Szkudelski T. The mechanism of alloxan and streptozotocin action of b-cells of the rat pancreas. Physiol. Res. 2001;50:537–546
  11. Urizar NL, Moore DD. GUGULIPID: natural cholesterol – lowering agent. Annu. Rev. Nutr. 2003;23:303–313
  12. Szekanecz Z, Koch AE, Kunkel SL, Strieter RM. Cytokines in rheumatoid arthritis. Potential targets for pharmacological intervention. Drugs Aging. 1998;12:377–390
  13. Nagarajan M, Waszkuc TW, Sun J. Simultaneous determination of E- and Zguggulsterones in dietary supplements containing Commiphora mukul extract (guggulipid) by liquid chromatography. JAOAC Int. 2001;84:24–28
  14. Lata S, Saxena KK, Bhasin V, Saxena RS, Kumar A, Srivastava VK. Beneficial effects of Allium sativam, Allium cepa and Commiphora mukul on experimental hypolipidemia and atherosclerosis, a comparative evaluation. J. Postgrad. Med. 1991;37:132–135
  15. Yalow RS, Berson SA. Immunoassay of plasma insulin in man. Diabetes. 1961;10:339
  16. Utley HG, Bernheim F, Hochstein P. Effect of sulfhydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys. 1967;118:29–32
  17. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990;186:464–478
  18. Ellman GL. Tissue sulphydryl. Arch. Biochem. Biophys. 1959;82:70–77
  19. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin's-phenol reagent. J. Biol. Chem. 1951;193:265–275
  20. Soon YY, Tan BKH. Evaluation of the hypoglycemic and antioxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats, Singapore. Med. J. 2002;43:77
  21. Beers RF, Sizer JW. Spectrophotometric method for measuring breakdown of hydrogen peroxide catalase. J. Biol. Chem. 1952;195:133–140
  22. Rotsruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973;179:588–590
  23. Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974;249:7130–7139
  24. Pinto RE, Bartley W. The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. Biochem. J. 1969;112:109–115
  25. Duncan DB. Multiple range and multiple tests. Biometrics. 1955;42:1–42
  26. Kavalali G, Tuncel H, Goksel S, Hatemi MH. Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats. J. Ethnopharmacol. 2002;84:241–245
  27. Raju J, Gupta D, Rao AR, Yadava PK, Baquer N. Trigonella foenumgraecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic gluconeogenic and lipogenic enzymes. Mol. Cell. Biochem. 2001;224:45–51
  28. Tomlinson KC, Gardiner SM, Hebden R, Bennet T. Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol. Rev. 1992;44:103–150
  29. Wilson GL, Hartig PC, Patton NJ, LeDoux SP. Mechanisms of nitrosourea induced β-cell damage. Activation of poly (ADP-ribose) synthetase and cellular distribution. Diabetes. 1988;37:213–216
  30. Swanston-Flat SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatment for diabetes: studies in normal and streptozotocin diabetic mice. Diabetologia. 1990;33:462–464
  31. Chatterjea MN, Shinde R. Text Book of Medical Biochemistry. New Delhi: Jaypee Brothers Medical Publishers; 2002;p. 317
  32. Davidson MB. Diabetes Mellitus: Diagnosis and Treatment. Hoboken, NJ: Wiley; 1981;p. 109
  33. Umesh CS, Yadav K, Moorthy K, Najma Z. Combined treatment of sodium orthovanadate and Mormodica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes an alloxan diabetic rat. Mol. Cell. Biochem. 2005;268:111–120
  34. Nityanand S, Kapoor NK. Cholesterol lowering activity of the various fractions of the guggul. Indian J. Exp. Biol. 1973;11:395–3987
  35. Urizer NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P. Yan, a natural product that lowers cholesterol as an antagonist ligand for the FXR. Science. 2002;3:(Science Express Report)
  36. Taleb-Senouci D, Ghomari H, Krouf D, Bouderbala S, Prost J, Lacaille-Dubois MA, et al. Antioxidant effect of Ajuga iva aqueous extract in streptozotocin-induced diabetic rats. Phytomedicine. 2009;16:623–631
  37. Nazirogilu M, Butterworth P. Protective effects of moderate exercise with dietary vitamin C and E on blood antioxidative defense mechanism in rats with streptozotocin-induced diabetes. Can. J. Appl. Physiol. 2005;30:172–185
  38. Maritim AC, Sanders RA, Watkins JB. Effects of -lipoic acid on biomarkers on oxidative stress in streptozotocin-induced diabetic rats. J. Nutr. Biochem. 2003;14:288–294
  39. Domingues C, Ruiz E, Gussinye M, Carrascosa A. Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care. 1998;21:1736–1742
  40. Yeh CT, Yen GC. Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 m RNA expression. J. Nutr. 2006;136:11–15
  41. Benhamou PY, Moriscot C, Richard MJ, Beatri O, Badet L, Pattou F, et al. Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets. Diabetologia. 1998;41:1093–1100
  42. Chen L, Xang X, Jiao H, Zhao B. Tea catechins protect against lead-induced cytotoxicity, lipid peroxidation and membrane fluidity in HepG2 cells. Toxicol. Sci. 2002;69:149–156
  43. Ceconi C, Cargnoni A, Pasini E, Condorelli E, Curello S, Ferrari R. Lipid peroxidation during myocardial reperfusion. Mol. Cell. Biochem. 1992;9:49–54
  44. Kojic G, Vlahonic P, Ravloure D. The possible importance of the cation binding site for the oxidative modification of liver nucleotidase. Arch. Physiol. Biochem. 1998;106:91–99
  45. Despres JP, Lemieux I, Dagenais GR, Cantin B, Lamarche B. HDL cholesterol as a marker of coronary heart disease risk: the Quebec cardiovascular study. Atherosclerosis. 2000;153:263–272

PII: S0928-4680(11)00031-9

doi: 10.1016/j.pathophys.2010.10.002

Pathophysiology
Volume 18, Issue 4 , Pages 255-261 , September 2011

Article Tools

* Image Usage & Resolution