Vascular mechanisms of cyanidin-3-glucoside response in streptozotocin-diabetic rats

Body weight and serum glucose concentration in STZ diabetic and control rat groups treated by C3G (cyanidin) and glibenclamide 0, 4 or 8 weeks (means±SEM). *p<0.05, **p<0.01, ***p<0.001 (as compared to week 0 in the same group); ^#p<0.05, ^##p<0.01, ^###p<0.005 (as compared to diabetics in the same week).

Cumulative concentration–response curves for KCl and PE in preparations of rat aortas after 8 weeks treatment (see Fig. 1 for explanations) in the presence (A) and absence (B) of endothelium (means±SEM). **p<0.01 (as compared to control); ^φp<0.05 (as compared to diabetic), ^§p<0.05 (as compared to control).

Cumulative concentration-response curves for ACh in rat aortic rings precontracted with PE after 8 weeks treatments (see Fig. 1 for explanations). Relaxation responses have been expressed as percentages. *p<0.05, **p<0.01 (as compared to control); ^φp<0.05 (as compared to diabetic), ^§p<0.05 (as compared to control).

MDA concentrations in aorta homogenate supernatant from different rat groups treated for 8 weeks (see Fig. 1 for explanations). *p<0.05, **p<0.01 (in comparison with control). ^#p<0.05 (in comparison with diabetic).

Superoxide dismutase (SOD) activity in aorta homogenate supernatant from different rat groups. (see Fig. 1 for explanations). *p<0.05 (in comparison with control).